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Congential Heart Disease & BAV

    
Congenital Heart Disease & BAV
Transposition of Great ArteriesTransposition of great arteries (TGA) is a severe congenital heart defect when a patient is born with the aorta and pulmonary arteries switched, causing serious complications due to low oxygen delivery to the body. TGA can be corrected by the arterial switch operation but one of the most common complications following this procedure involves the narrowing of the pulmonary arteries. Narrowing of blood vessels (or stenosis) can be detected by areas of high blood flow velocity. This research focuses on using 4D flow MRI to detect stenosis by measuring the peak velocities in the pulmonary arteries and aorta in patients after the arterial switch operation.

Investigators: Kelly Jarvis (MS), Susanne Schnell (PhD), Alex Barker (PhD),Marleen Vonder (MS), Michael Rose (BS), James Carr (MD), Joshua D. Robinson(MD), Michael Markl (PhD), Cynthia K. Rigsby (MD)

Funding: National Institutes of Health, American Heart Association

Publications:
4D Flow MRI Improves Assessment of Aortic and Pulmonary Peak Velocities in Patients With D-Transposition of Great Arteries Following Arterial Switch Operation


 

Fontan

Evaluation of Fontan Circulation using 4D flow MRI

In severe cases, a patient is born with only one fully functioning ventricle and must undergo a series of surgeries to deliver blood to the heart and lungs. The final surgical procedure creates the Fontan circulation which results in systemic venous return being supplied directly to the lungs through the pulmonary arteries without passing through the systemic ventricle. Non-uniform distribution of caval blood flow to the left and right lung is suspected to cause complications in patients with Fontan circulation. Using 4D flow magnetic resonance imaging (4D flow MRI), we can visualize and quantify flow differences among SVP patients with Fontan circulation in-vivo. Additionally, preliminary studies provide evidence of a direct link between Fontan geometry and changes in flow distribution. Building on these results, we will develop 3D anatomic and 4D flow MRI tools for the improved definition of Fontan geometry and the subsequent quantification of blood mixing by probabilistic 3D flow connectivity mapping. Our goal is to improve the assessment of Fontan function by investigating novel quantitative measures of blood mixing and exploring their relationship with Fontan geometry and patient outcome, as defined by the presence of failing Fontan symptoms.

Investigators: Kelly Jarvis (MS), Susanne Schnell (PhD), Ramona Lorenz (PhD), Alex J. Barker (PhD), Julio Garcia (PhD), Maya Gabbour (MD), Michael Rose (BS), Varun Chowdhary (MD), James Carr (MD), Andrada R. Popescu (MD), Roger A. de Freitas(MD), Joshua D. Robinson (MD), Cynthia Rigsby (MD), Michael Markl (PhD)

Funding: National Institutes of Health, American Heart Association

Publication:
In vivo quantification of blood mixing in single ventricle patients with Fontan circulation using 4D flow MRI