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Cerebral Vascular Disease


4D Flow in Intracranial Aneurysms

We employed 4D-flow MRI for the comprehensive in-vivo analysis of hemodynamics and its relationship to size and morphology of different intracranial aneurysms (IA). 4D flow MRI demonstrated the influence of lesion size and morphology on aneurysm hemodynamics suggesting the potential of 4D-flow MRI to assist in the classification of individual aneurysms.

Investigators: Susanne Schnell (PhD), Sameer A. Ansari (PhD, MD), Michael Markl(PhD)

Funding: German Research Foundation, SIR Reasearch Pilot Grant, and RSNA Research Seed Grant

Three-dimensional hemodynamics in intracranial aneurysms: influence of size and morphology




4D Flow in Cerebral AVMs

Arteriovenous malformations are an important etiology of hemorrhagic stroke. However, current imaging modalities and risk do not provide insights into individual AVM hemodynamics and its role in pathophysiology. The aims of this project is to determine whether intracranial 4D flow MR imaging can provide insights into arteriovenous malformation hemodynamics independent of the Spetzler-Martin grade and to report the changes in flow observed during staged embolization.

Investigators: Can Wu, Susanne Schnell (PhD), Michael Markl (PhD), Sameer A. Ansari (PhD, MD), Ali Shaibani (MD)

Funding: here (hyperlinks to fundings page)

Intracranial 4D flow MRI: toward individualized assessment of arteriovenous malformation hemodynamics and treatment-induced changes